2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143993S
    Maytansinoid DM4 impurity 3-d6
    Maytansinoid DM4 impurity 3-d6 is the deuterium labeled Maytansinoid DM4 impurity 3[1].
    Maytansinoid DM4 impurity 3-d<sub>6</sub>
  • HY-W008216R
    HMMNI (Standard)
    HMMNI (Standard) is the analytical standard of HMMNI. This product is intended for research and analytical applications. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
    HMMNI (Standard)
  • HY-12753S
    Debutyldronedarone-d7
    		≥98.0%
    Debutyldronedarone-d7 is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans.Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].
    Debutyldronedarone-d<sub>7</sub>
  • HY-78841
    (2S,4S)-Sacubitril
    (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure.
    (2S,4S)-Sacubitril
  • HY-133695
    Florfenicol amine
    Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine
  • HY-143965S
    Imidacloprid impurity 2-d4 hydrochloride
    Imidacloprid impurity 2-d4 (hydrochloride) is the deuterium labeled Imidacloprid impurity 2-d4 (hydrochloride)[1].
    Imidacloprid impurity 2-d<sub>4</sub> hydrochloride
  • HY-103252S
    Monomethyl fumarate-d3
    		98.57%
    Monomethyl fumarate-d3 is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate[1].
    Monomethyl fumarate-d<sub>3</sub>
  • HY-135375
    O-Methyl Atorvastatin calcium
    O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    O-Methyl Atorvastatin calcium
  • HY-131275
    Imatinib Impurity E
    Imatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.
    Imatinib Impurity E
  • HY-G0007S
    Omeprazole sulfone-d3
    Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
    Omeprazole sulfone-d<sub>3</sub>
  • HY-148846
    Mosapride N-Oxide
    Mosapride N-Oxide is a major active metabolite of Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
    Mosapride N-Oxide
  • HY-133797
    Cyclobenzaprine N-oxide
    Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine.
    Cyclobenzaprine N-oxide
  • HY-W021399S
    Lidocaine impurity 5-d6
    Lidocaine impurity 5-d6 is deuterium labeled Lidocaine impurity 5.
    Lidocaine impurity 5-d<sub>6</sub>
  • HY-143987S
    DM51 impurity 1-d9
    DM51 impurity 1-d9 is the deuterium labeled DM51 impurity 1[1].
    DM51 impurity 1-d<sub>9</sub>
  • HY-147336
    Desmethylazelastine
    Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
    Desmethylazelastine
  • HY-119532
    Nordeprenyl
    Nordeprenyl is the metabolite of Deprenyl. Deprenyl is a potent, selective and irreversible inhibitor of MAO-B. Nordeprenyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Nordeprenyl
  • HY-G0025
    Tetrabenazine Metabolite
    Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
    Tetrabenazine Metabolite
  • HY-P3147
    IYPTNGYTR
    IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism.
    IYPTNGYTR
  • HY-W015332R
    Captopril EP Impurity D (Standard)
    Captopril EP Impurity D (Standard) is the analytical standard of Captopril EP Impurity D. This product is intended for research and analytical applications. Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity D (Standard)
  • HY-136428
    Desoxycarbadox
    Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.
    Desoxycarbadox
Cat. No. Product Name / Synonyms Application Reactivity